Selective Cell Surface Expression of Thymus Leukemia Antigen during S Phase of the Cell Cycle
Open Access
- 1 March 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 122 (3) , 1121-1125
- https://doi.org/10.4049/jimmunol.122.3.1121
Abstract
The expression of the thymus leukemia antigen (TL) was studied on a murine leukemia cell line (ASL-1W) grown in vitro and separated into cell cycle phases by velocity sedimentation or growing synchronously in culture. The expression of TL was determined qualitatively by direct cytotoxicity and quantitatively by a modified inhibition of cytotoxicity assay. TL expression was found to vary with DNA synthesis. The hypothesis that expression is coordinately regulated with DNA synthesis, and the relationship of this to the restricted expression of TL on rapidly dividing cells is discussed.This publication has 2 references indexed in Scilit:
- Antigenic Properties of Experimental Leukemias. I. Serological Studies In Vitro With Spontaneous and Radiation-Induced Leuke-mias2JNCI Journal of the National Cancer Institute, 1963
- Cell population kinetics in the intestinal epithelium of the mouseExperimental Cell Research, 1959