Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies
- 1 May 2005
- journal article
- research article
- Published by Elsevier in Annals of Oncology
- Vol. 16 (suppl 4) , iv44-iv49
- https://doi.org/10.1093/annonc/mdi907
Abstract
Mutations in the Ki-ras and TP53 genes are the most frequently observed genetic alterations in colorectal cancer (CRC). Ki-ras mutations are mostly found in codons 12 and 13, and less in codon 61. The majority of the TP53 mutations occur in the core domain which contains the sequence-specific DNA binding activity of the protein, and they results in loss of DNA binding.Keywords
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