Characterization of the stimulus-response curve for hypoxic pulmonary vasoconstriction
- 1 July 1983
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 398 (2) , 93-95
- https://doi.org/10.1007/bf00581054
Abstract
Lungs from seven healthy female, sea level rats were perfused and ventilated in vitro. Hypoxic pulmonary vasoconstriction was stimulated by changing the inspired gas from 21% oxygen to 6, 4, 3 or 0% oxygen (all gases contained 5% carbon dioxide and balance nitrogen). A sigmoid stimulus-response curve was derived by probit analysis with a 50% of maximum response (ED50) at an oxygen tension of 3.49±0.17 kPa. It is suggested that such characterizations of the response to hypoxia may allow a more precise comparison of the effects of species, age, sex and drugs on hypoxic pulmonary vasoconstriction.This publication has 16 references indexed in Scilit:
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