Mechanism of decrease in plasma renin activity during volume expansion

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Abstract
The importance of filtered load of sodium and extracellular volume expansion (ECVE( per se on plasma renin activity (PRA) was studied in two groups of hydropenic dogs. Group I protocol consisted of bilateral ureteral obstruction (UO) followed by isotonic ECVE and finally UO release. During UO, PRA rose significantly above control (15.4 leads to 41.7 ng/ml per h). Superimposition of ECVE did not significantly alter PRA, but UO release returned PRA toward control (24.8 ng/ml per h). Fractional sodium excretion (FE(Na)) after UO release was higher than control (0.6 leads to 12.6%). In group II, ECVE preceded UO and caused a fall in PRA below control (16.8 leads to 4.8 ng/ml per h). FE(Na) was significantly increased over control (0.3 leads to 14.7%). Superimposition of UO reversed the fall in PRA to a value not significantly different from control. On release of UO PRA fell, but not significantly, whereas FE(Na) fell to 12.6%, a value not different from that during ECVE alone. The results indicate that filtration is required for ECVE to elicit a fall in PRA, under the present experimental condition.

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