The Effect of Oral Ethanol on Glutamic Pyruvic and Glutamic Oxalacetic Transaminase Activity in the Rat Liver

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Abstract
The effect of the ingestion of 20% alcohol as the sole source of fluid, on the glutamic pyruvic (GPT) and glutamic oxalacetic (GOT) transaminase activity in rat livers was compared with pair-fed, isocaloric and pair-fed and ad lib-fed controls under conditions of varying food intake, in two experiments. All animals received adequate amount of vitamins and lipotropic factors throughout. At 24 weeks, the hepatic GOT /GPT ratio was significantly higher in the alcohol fed group as compared with the pair-fed, water-fed controls. In both experiments, a significant diminution of hepatic GPT in the alcohol-fed animals, as compared with any of the controls, and independent of calorie intake was observed. This change was not observed in a control tissue (brain). Upon starvation there was a significant increase in hepatic GOT activity in the alcohol-fed group and the pair-fed controls only. These changes are interpreted as evidence for a direct action of alcohol on the liver of rats.

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