Antibiotic Tolerance Induced by Lactoferrin in Clinical Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients
- 1 April 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (4) , 1613-6
- https://doi.org/10.1128/aac.49.4.1613-1616.2005
Abstract
Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginosa isolates from cystic fibrosis patients showed higher ATE values (≤6-fold) than other clinical strains.Keywords
This publication has 14 references indexed in Scilit:
- A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistanceNature, 2003
- Susceptibility Testing of Pseudomonas aeruginosa Isolates and Clinical Response to Parenteral Antibiotic AdministrationChest, 2003
- Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane.Biochemistry (Moscow), 2003
- New antimicrobials in the management of cystic fibrosisJournal of Antimicrobial Chemotherapy, 2002
- Alginate Overproduction AffectsPseudomonas aeruginosaBiofilm Structure and FunctionJournal of Bacteriology, 2001
- Synergistic Fungistatic Effects of Lactoferrin in Combination with Antifungal Drugs against Clinical Candida IsolatesAntimicrobial Agents and Chemotherapy, 1999
- The effect of human lactoferrin on the MICs of doxycycline and rifampicin for Burkholderia cepacia and Pseudomonas aeruginosa strains.Journal of Antimicrobial Chemotherapy, 1999
- LYSOZYME AND LACTOFERRIN IN SPUTUM FROM PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG-DISEASE1984
- Roles of ribosomal binding, membrane potential, and electron transport in bacterial uptake of streptomycin and gentamicinAntimicrobial Agents and Chemotherapy, 1983
- Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 1981