1,4-Palladium Migration via C−H Activation, Followed by Arylation: Synthesis of Fused Polycycles
- 28 August 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (38) , 11506-11507
- https://doi.org/10.1021/ja035121o
Abstract
A novel palladium migration/arylation methodology for the synthesis of complex fused polycycles has been developed, in which one or more sequential Pd-catalyzed intramolecular migration processes involving C−H activation are employed. The chemistry works best with electron-rich aromatics, which is in agreement with the idea that these palladium-catalyzed C−H activation reactions parallel electrophilic aromatic substitution.Keywords
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