The independence of germ-cell genotype from somatic influence in chimaeric mice

Publisher Website
Google Scholar
Abstract
SUMMARY: Mouse chimaeras made by aggregating embryos homozygous for nine recessive genes with embryos carrying the corresponding dominants were mated with partners of the recessive strain. Progeny were either of the recessive type for all loci examined, or showed the dominant characters at all loci. Tail length in homozygous vestigial-tail progeny was unaffected by whether the fertilizing spermatozoon had undergone maturation in a chimaera or in a control vestigial-tail male. There was thus no indication that the germ cells had been in any way modified by their intimate association with germ cells and somatic tissue of contrasting genotype in the chimaeras.