Modification of Cellular Membrane Functions by Pendolmycin
- 1 January 1989
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 80 (1) , 15-18
- https://doi.org/10.1111/j.1349-7006.1989.tb02238.x
Abstract
Pendolmycin is a new indole alkaloid isolated from Nocardiopsis as an inhibitor of phosphatidylinositol turnover. Structurally, pendolmycin is similar to teleocidin B and lyngbyatoxin A. Pendolmycin, teleocidin B and 12-O-tetradecanoylphorbol-13-acetate all inhibited phosphatidylinositol turnover in A431 cells. Pendolymycin inhibited binding of epidermal growth factor, activated arachidonic acid release and hexose transport, and inhibited binding of phorbol-12,13-dibutylate in C3H10T1/2 cells. Thus, pendolymcin was as potent as teleocidin B and phorbol ester tumor promoters in modification of cell membrane functions, while having the simplest structure among them.Keywords
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