THE DEHYDRATING EFFECT OF CONTINUOUSLY ADMINISTERED WATER

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Abstract
A steady state of oral water intake in man was found to result in a total output of fluid larger than the intake, and if continued leads to the production of negative water loads. The urinary output rate alone was 8% greater than the intake rate. The ratio of rate of chloride excretion to rate of excess water excretion is equal to the normal plasma conc. in the steady state, and an equation of steady state is derived. The threshold of appearance and the threshold of retention are defined and are illustrated for Cl. In renal excretion, the regulation of conc. of plasma Cl takes precedence over the regulation of body vol., when water is drunk.

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