THE EQUATION EXPRESSING THE EXCRETION OF A DIURETIC AND ITS RELATION TO DIFFUSION PROCESSES

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Abstract
Chloride threshold is defined as the highest value or limit of Cb (plasma concentration) at which Cu (urine concentration) is < Cb for all rates of urine flow. Injection of glucose has no effect on chloride threshold, even with injection of 300 cc. 5% solutions. Injection of sulphate or urea in saline does cause a marked increase in chloride threshold. From premises of the diffusion-secretion theory, it is shown that the rate of absorption of NaCl is directly proportional to the threshold, minus plasma concentration, and that at a constant plasma concentration the absorption ratio is proportional to the time of unit volume of urine. The diffusion secretion theory is shown to be in harmony with facts established in other lines of renal research.

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