Synthesis and pharmacological evaluation of N-substituted 4,6-diaryl-3-pyridazinones as Analgesic, antiinflammatory and antipyretic agents.

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Abstract
The synthesis and the pharmacological evaluation of 19 new 4,6-diaryl-3-pyridazionones are reported. All compounds were screened for analgesic, antiinflammatory and antipyretic activities. Introduction of an arylpiperazinomethyl moiety in the 2-position of the pyridazinone ring resulted in the most potent activities. Compounds 2a, 2b, 2h and 2i exhibited a higher analgesic activity than did aspirin or noramidopyrine in the hot plate test.