Potentiation of tissue culture rabies vaccine by adjuvants.

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Abstract
Water-in-oil, aluminum hydroxide and aluminum phosphate adjuvants enhance the magnitude and raidity of the serological response in rabbits to rabies vaccines prepared in tissue culture. Tissue culture vaccines were tested along with a rabbit brain rabies vaccine. In neutralization tests, a tissue culture vaccine prepared so as to contain no animal serum was just as effective as one containing serum, provided an adjuvant was added to them. Both induced antibody titers which were higher and were sustained longer than those evoked by the rabbit brain vaccine. Rabbits immunized with any of the tissue culture vaccines were able to withstand substantial challenge with Street rabies virus.