Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta.
- 1 February 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (2) , 586-589
- https://doi.org/10.1073/pnas.72.2.586
Abstract
Cells obtained from normal human skin synthesize predominantly type I collogen in culture. Cells obtained from the skin of an infant with a severe form of osteogenesis imperfecta were found to synthesize as much type III as type I collagen. Decreased synthesis of type I collagen could explain the tissue fragility observed in this case.Keywords
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