Acclimation to cold and norepinephrine; effects of immunosympathectomy

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Abstract
Immunosympathectomized (nerve-growth factor antiserum-treated) rats acclimated to 23 C excrete less norepinephrine than normal rats, but no difference in excretion was found between antiserum-treated and normal animals that had been acclimated to cold. Normal and antiserum-treated rats, with or without adrenal medullas, were acclimated to cold and then subjected to severe cold stress produced by removal of the fur. Normal as well as nerve-growth factor antiserum-treated rats responded with a temporary increase of urinary norepinephrine excretion[long dash]antiserum-treated rats less than normal rats[long dash]that reached a maximum after 24 hr.