SELECTIVE EXPRESSION OF PATERNAL HUMAN MAJOR HISTOCOMPATIBILITY ANTIGENS ON THE SURFACE OF HYDATIDIFORM MOLE CELLS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 69  (6) , 849-853
Abstract
The HLA typing of 2 cases of invasive hydratidiform mole showed that the fibroblast-like cells and trophoblasts from the mole selectively expressed paternal HLA haplotype specificity but not maternal HLA on the surface. This result supported the notion of androgenetic origin of hydratidiform mole from the aspects of HLA specificity. Immunological implications of this finding and development of chorionic tumor were discussed in the light of fetomaternal relationship and host immune surveillance against the tumor.

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