STUDIES OF FAT METABOLISM IN ATHEROSCLEROSIS BY ISOTOPIC METHODS

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Abstract
Summary: An isotopic lipid tolerance test is described. An assessment of this test on 40 patients with abnormal lipid metabolism and 12 controls has given the following results : (i) I131 glyceryl trioleate is a satisfactory tracer of lipid metabolism. (ii) The results of the test are consistent and reproducible. (iii) Patients with coronary atherosclerosis show raised lipid blood radioactivity levels during the first few hours, and these persist to 72 hours, when there is more complete separation between atherosclerotic and normal subjects. (iv) The lipid clearance time is prolonged in almost all patients with coronary heart disease. (v) The results give further support to the apparent linkage of atherosclerosis and disordered lipid metabolism. (vi) The lipid tolerance test described gives a method of assessing the degree of lipid metabolic disorder.