Evidence for two populations of B-L (Ia-Like) molecules encoded by the chicken MHC
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 13 (5) , 381-391
- https://doi.org/10.1007/bf00346019
Abstract
Two specific alloantisera detecting B-L (Ia-like) antigens on chicken lymphocytes of the B 6 and B 15 haplotypes were found to cross-react strongly. Anti-B-L6 and anti-B-L15 alloantisera both reacted with B-L molecules on B6 and B15 lymphocytes as demonstrated by immunofluorescence and SDS-PAGE analysis of 125I-labeled B-L antigens isolated by incubation with anti-B-L alloantisera. Absorption studies showed that the anti-B-L alloantisera reacted with at least two kinds of antigenic determinant, one set shared by B-L6 and B-L15 molecules and another set specific for each haplotype. In spite of the absence of genetic evidence for more than one B-L locus in the chicken B complex, it was shown by sequential antibody incubations that these two different B-L antigenic determinants are associated with at least two separate species of B-L molecules, indicating the presence of at least two B-L loci within the MHC of the chicken.This publication has 36 references indexed in Scilit:
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