-Lactam Antibiotic Production by Streptomyces clavuligerus Mutants Impaired in Regulation of Aspartokinase
- 1 July 1983
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 129 (7) , 2063-2069
- https://doi.org/10.1099/00221287-129-7-2063
Abstract
SUMMARY: This work describes isolation and characterization of Streptomyces clavuligerus mutants resistant to the lysine analogue S-(2-aminoethyl)-L-cysteine (AEC). The mutation to AEC resistance was shown to affect the feedback regulation of aspartokinase; 70% of the mutants isolated had aspartokinase activity insensitive to concerted feedback inhibition by lysine plus threonine. Among these mutants, 70% (about 50% of the total AEC-resistant strains isolated) showed significant overproduction of β-lactam antibiotics.This publication has 6 references indexed in Scilit:
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