Benzodiazepine Receptors on Primary Cultures of Mouse Astrocytes
- 1 April 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (4) , 1587-1589
- https://doi.org/10.1111/j.1471-4159.1981.tb00603.x
Abstract
Benzodiazepines bind to glial membranes on a single type of site, with a high affinity (KD= 5 × 10−9 M) on about 100 fmol of sites per mg protein. The number of binding sites is increased when the membranes are treated with Triton X‐100. Antiepileptic drugs such as clonazepam and phenobarbital and hypnotic drugs such as Ro‐11‐3128 and Ro‐11‐6896 are able in pharmacological concentrations to displace [3H]flunitrazepam from its glial binding sites.Keywords
This publication has 12 references indexed in Scilit:
- GABA Receptors in Clonal Cell Lines: A Model for Study of Benzodiazepine Action at Molecular LevelScience, 1979
- GABA metabolism in cultured glial cellsNeurochemical Research, 1979
- Benzodiazepine receptor: Photoaffinity labeling and localizationEuropean Journal of Pharmacology, 1979
- CHARACTERIZATION OF BENZODIAZEPINE BINDING SITES IN CULTURED CELLS OF NEURAL ORIGINJournal of Neurochemistry, 1979
- Cellular localization of [3H]-diazepam receptorsNeuropharmacology, 1978
- Lack of brain specific benzodiazepine receptors on mouse primary astroglial culturesNeuroscience Letters, 1978
- Benzodiazepine Receptor: Demonstration in the Central Nervous SystemScience, 1977
- Distribution of Anticonvulsant Drugs in Gray and White Matter of Human BrainCanadian Journal of Neurological Sciences, 1977
- Possible relationship between glial cells, dopamine and the effects of antipsychotic drugsNature, 1977