ACTIONS OF ADRENALINE AND ACETYLCHOLINE ON THE DENERVATED IRIS OF THE CAT AND MONKEY

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Abstract
The denervated iris of the cat and monkey differs in the reactions to the autonomic drugs. In general, the cat responds with its dilator while the monkey reacts with its constrictor-fibers of the iris. Intraven. injs. of adrenaline produce a dilatation of the completely denervated iris in the cat but a delayed miosis in the monkey. Intraven. injs. of acetylcholine produce an inconstant constriction and a more frequent secondary dilatation in the cat while in the monkey there is only constriction. The pupillary dilatation obtained with injs. of acetylcholine in the cat is usually abolished by bilateral adrenalectomy. The pupillary constriction which is noted on intraven. injs. of adrenaline in the monkey is potentiated by eserinization and occurs only while the constrictor fibers of the aris are sensitive to acetylcholine. Excess of acetylcholine apparently stimulates the secretion of adrenaline and excess of adrenaline stimulates the liberation of a cholinergic-like substance in the body.

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