A COMPARISON OF THE EFFECTS OF SYMPATHIN AND ADRENINE ON THE IRIS

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Abstract
The effects were recorded of the action of adrenine, hepatic sympathin and cardio-pulmonary sympathin on the nictitating membrane and the iris of cats. When the 3 stimulating agents evoked nearly equal responses of the membrane, adrenine caused a marked dilatation of the pupil, cardiac sympathin caused slight widening, and hepatic sympathin only minor and not consistent effects. Severance of the circular muscle of the iris increased the enlargement of the pupil elicited by sympathin. These results are discussed and the tentative conclusions are reached that sympathin E, unlike adrenine, may affect not only the dilator but also the constrictor muscle of the iris, and that the differences between cardio-pulmonary and hepatic sympathin may be attributed to the presence of sympathin I in the former and its absence from the latter.

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