Effects of Insulin on the Tracer-determined Distribution and Production of Glucose in Liverless Dogs

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Abstract
New evidence for an extrakepatic, splanchnic glucose production in dogs is provided. Insulin could not be shown, by the technics applied, to cause a decrease in this extrahepatic production of glucose. Removal of the liver does not abolish in every case the increase in apparent glucose space produced by exogenous insulin, although the increases, if present at all, are smaller and more variable than previously reported in normal dogs.