EFFECTS OF INSULIN ON RATES OF GLUCOSE TRANSFER IN THE DEPANCREATIZED DOG

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Abstract
A trace dose of radioactive glucose was injected into each of 6 postabsorptive depancreatized dogs which had been deprived of exogenous insulin for 66 hours. Blood samples were collected before and after the intravenous injection of insulin, and plasma glucose concentration and specific activity were measured. Insulin was found to cause an abrupt and marked increase in the rate of disappearance of glucose, and this increased rate became less with time, reaching the preinsulin level in about 90 minutes. Insulin caused a slower and much smaller decrease in the rate of appearance, but the decrease became greater with time during the 3 hour period of observation. Thus, it appeared that insulin acted in vivo both to increase the utilization of glucose and to decrease its production, but the effects differed in magnitude and in speed of response.