Mechanism of Hypoglycemia Responsiveness in Relation to Changes in Blood Eosinophile Level.

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Abstract
The intraven. admn. of 0.1 unit of crystalline insulin/kilo body wt. to the intact anesthetized dog caused an abrupt decline of the blood sugar level which is followed within 20-45 min. by a sharp rise. This is accompanied by a significant rise of the eosinophil level. The adreno-demedullated animal shows normal hypoglycemia responsiveness in the insulin tolerance test and an accompanying rise of the eosinophil level similar to that of the intact animal. In the adrenalectomized and hypophysectomized animals a rise of the eosinophil level similar to that of the normal was demonstrated after insulin, even though the blood sugar changes showed no evidence of hypoglycemia responsiveness. This is interpreted to signify that the mechanism for hypoglycemia responsiveness in the hypophysectomized and adrenalectomized animal is intact but is not apparently due to depletion of liver glycogen in the absence of the anterior-pituitary and adreno-cortical secretions.