THE ACTION OF INSULIN

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Abstract
Authors'' summary: The main points, which will be found summarized under the heading "General theory of insulin action," lead to the conclusion that insulin acts on the chain of reactions which leads, in the liver as well as in other tissues, from blood-glucose to tissue hexose-monophos-phate. The biochemical mechanism of this action is discussed and it is shown that the only explanation which seems compatible with all the actually known facts is that insulin facilitates simultaneously the adsorption of glucose to a specific enzymatic system responsible for the conversion of glucose into an active, labile form, which is subsequently phosphoryl-ated by adenosine-triphosphate, and for the oxidation of various carbohydrate derivatives, particularly of pyruvic acid, this process being coupled with the former. Some aspects of the action of insulin on protein metabolism and of the antagonism between insulin and adrenalin are finally discussed. A footnote adds, "The authors wish to make it clear that when this paper was sent in for publication, the later American literature was not yet available in Belgium. Even though some of the facts and theories discussed in these later chapters may now appear obsolete in the light of recent findings on glucose phosphorylation by the Coris and their co-workers, they have preferred not to alter the original text[long dash]and to go on stating the case as they were able to make it out under the conditions of enforced isolation imposed by the war.".

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