Characterization of the principal metabolite of quinine in human urine by 1 H-n.m.r. spectroscopy
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 21 (4) , 447-450
- https://doi.org/10.3109/00498259109039484
Abstract
1. The major metabolite of quinine in human urine, which is also the sole metabolite in human plasma and saliva, has been identified and characterized by chemical ionization mass spectrometry and 1H-n.m.r. spectrometry. 2. The mass spectrum showed that an oxygen atom is incorporated in the quinuclidine nucleus, and the exact position of the oxidation was established from the n.m.r. spectrum to be at the C-3 position.Keywords
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