Effect of potassium on secretion and potential of frog's gastric mucosa in Cl–-free solutions

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Abstract
In previous work it was shown that the potential difference of the secreting mucosa bathed in Cl–-free solutions (SO4– replacing Cl–) is negative (nutrient side negative). In the present work it was found that an increase of the K+ concentration (K+ substituted for Na+) of the bathing fluid on the secretory side produced an increase in H+ secretory rate. The effect of voltage-clamping at zero and at +100 mv on the H+ rate, with various K+ concentrations in the bathing fluids, yielded results predicted by the electrogenic H+ theory, but not by a forced exchange concept.

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