The effect of electric current on HCl secretion by isolated frog gastric mucosa

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Abstract
Currents up to 50 ma./sq. cm. were passed through isolated frog gastric mucosa, in directions both enhancing and opposing the natural p.d. In gastric mucosae secreting acid, enhancing currents (from nutrient to secretory side) increased the QHCl: f[degree]r 0.4 ma./sq. cm., mean [DELTA] QHCl = 1.2 [plus or minus] 0.2. Similar opposing currents decreased the QHCl by the same order of magnitude; in many cases secre tion was stopped. Four secretive gastric mucosae, not initially secreting acid, commenced to do so when an enhancing current was passed through them; in 4 other secretive gastric mucosae acid secretion was not initiated by enhancing currents. In all cases current passed through nonsecretive gastric mucosa failed to initiate acid secretion. No other membranes examined (eso -phageal, pyloric, duodenal and rectal mucosae, frog skin, cellophane and dead gastric mucosa) produced HC1 with any currents applied.