Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci
- 1 November 1986
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 74 (3) , 280-283
- https://doi.org/10.1007/bf00282549
Abstract
In nine family pedigrees in which X-linked agammaglobulinemia (XLA) is segregating, a multi-point linkage analysis has been carried out. In each family, the map distance, d, between XLA and a fixed point in a known map of nine RFLP loci on the X chromosome was estimated by calculating the log likelihoods, L(d). Using a new method, the 10-point likelihood was approximated by appropriately combining three 4-point likelihoods. Homogeneity tests (admixture tests) were performed showing clear evidence for heterogeneity of XLA.Keywords
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