X-linked agammaglobulinemia and the red blood cell determinants Xg and 12E7 are not closely linked
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 68 (4) , 303-309
- https://doi.org/10.1007/bf00292589
Abstract
Studies on the segregation of the red blood cell determinant Xg in 12 families with X-linked inheritance of agammaglobulinemia (XLA) in 3–4 generations suggested linkage of Xg with XLA. One extensive pedigree of a Dutch family with XLA in eight generations was investigated for Xg and the quantitative polymorphism 12E7. LIPED analysis indicated linkage disproven up to 25cM distance within this pedigree. Taken together with data obtained from two other informative XLA pedigrees and with published data, the results indicate no close linkage between XLA and Xg:12E7, the distance between XLA and Xg being more than 20cM.This publication has 20 references indexed in Scilit:
- Genetic linkage relationships between the Xg blood group system and two X chromosome DNA polymorphisms in families with Duchenne and Becker muscular dystrophyHuman Genetics, 1983
- Linkage studies in a family with X-linked recessive ichthyosis employing a cloned DNA sequence from the distal short arm of the X chromosomeHuman Genetics, 1983
- Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosomeNature, 1983
- Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophyNature, 1982
- A human quantitative polymorphism related to Xg blood groupsNature, 1981
- Linkage of genes for chronic granulomatous disease and XgHuman Genetics, 1980
- Assignment by deletion mapping of the steroid sulfatase X-linked ichthyosis locus to Xp223Human Genetics, 1980
- Evidence that murine pre-B cells synthesise μ heavy chains but no light chainsNature, 1979
- Human X Chromosome Carries Quantitative Genes for Immunoglobulin MScience, 1972
- A SEX-LINKED BLOOD GROUPThe Lancet, 1962