Lipase-catalyzed Stereoselective Hydrolysis of 2-Acyloxy-3-chloropropylp-toluenesulfonate
- 1 February 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 50 (2) , 375-380
- https://doi.org/10.1080/00021369.1986.10867377
Abstract
Lipase-catalyzed stereoselective hydrolysis of 2-acyloxy-3-chloropropyl p-toluenesulfonate (1) was investigated. From the screening tests, lipases from Pseudomonas aeruginosa, Aspergillus niger, Mucor species, Rhizopus delemar and Rhizopus japonicus were found to hydrolyze (R,S)-1 stereoselectively to afford (R)-1 and (S)-2-hydroxy-3-chloropropyl p-toluenesulfonate (2). Among these enzymes, the lipase from Pseudomonas aeruginosa was found to possess the highest hydrolytic activity and stereoselectivity in more than 99% e.e.This publication has 11 references indexed in Scilit:
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