Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin
- 1 March 2008
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (3) , 1144-1146
- https://doi.org/10.1128/aac.01542-07
Abstract
Incomplete killing was observed for caspofungin against Candida glabrata , which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δ slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.Keywords
This publication has 25 references indexed in Scilit:
- Paradoxical Effect of Echinocandins across Candida Species In Vitro: Evidence for Echinocandin-Specific and Candida Species-Related DifferencesAntimicrobial Agents and Chemotherapy, 2007
- In Vitro Pharmacodynamics of Anidulafungin and Caspofungin against Candida glabrata Isolates, Including Strains with Decreased Caspofungin SusceptibilityAntimicrobial Agents and Chemotherapy, 2006
- Characterizing the Effects of Caspofungin on Candida albicans , Candida parapsilosis , and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect ExperimentsAntimicrobial Agents and Chemotherapy, 2006
- Comparison of the Fungicidal Activities of Caspofungin and Amphotericin B against Candida glabrataAntimicrobial Agents and Chemotherapy, 2005
- Promoter-dependent disruption of genes: simple, rapid, and specific PCR-based method with application to three different yeastCurrent Genetics, 2005
- Caspofungin in Combination with Amphotericin B against Candida glabrataAntimicrobial Agents and Chemotherapy, 2005
- Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole, and Echinocandin Antifungal Agents in Saccharomyces cerevisiaeJournal of Biological Chemistry, 2003
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- The protein kinase C‐mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiaeMolecular Microbiology, 1999
- Influence of Test Conditions on Antifungal Time-Kill Curve Results: Proposal for Standardized MethodsAntimicrobial Agents and Chemotherapy, 1998