Drug-Induced End-Stage Renal Disease

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Abstract
Chronic tubulointerstitial nephritis and nephritis of unknown origin account for 15 to 30 percent of the cases of end-stage renal disease (ESRD) in the United States and Europe. A substantial but as yet undetermined proportion of these cases may be due to drug-induced nephrotoxicity. Evaluating the role of nephrotoxic drugs is a critical health care issue because of the opportunity to prevent ESRD. In 1953 Spuhler and Zollinger1 suggested that the prolonged ingestion of analgesic drugs could cause tubulointerstitial nephritis (so-called analgesic nephropathy), and subsequently many studies confirmed their hypothesis. As a consequence, phenacetin was withdrawn from the market. The . . .