Clonal stability and phenotypic expression of chick cartilage cells in vitro.

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Abstract
Expression of the differentiated phenotype of embryonic chick cartilage cells is influenced by the medium (embryo extract supplement), the cell density, and the growth phase of the cells. It was possible to obtain clonal and mass culture loss of detectable function, like that previously reported for cartilage cells, as well as clonal retention of function, like that known for skeletal muscle and pigment cells. The apparent paradox was resolved: even after many cell generations most of the cells in a "dedifferentiated" population are capable of re-expressing their differentiated phenotype.