Effect of Heparin on Fate of Intravenously Administered Fat Emulsions in Rats.

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Abstract
Addition of heparin to intraven. admn. fat emulsion in rats resulted in a marked increase in rate of disappearance of fat from blood and a decrease in accumulation of fat in spleen and liver. Heparin apparently caused a change in the physical state of the fat in blood, resulting in decreased turbidity, and this altered fat rapidly left the blood. Lipemic blood from rats either fed fat or injd. with fat emulsion showed elevated serum hemoglobin concns. Injn. of heparin with fat emulsion resulted in higher serum hemo-blobin levels than injn. of fat emulsion alone, but this difference was seen only when the blood was allowed to stand for a period after it had been drawn.

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