Malignant giant cell tumor of soft parts. An ultrastructural study of four cases

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Abstract
Four cases of malignant giant cell tumor of soft parts (MGCT) were studied ultrastructurally. Most of the cells in 3 patients were identified as undifferentiated mesenchymal cells and mononuclear monohistiocytic cells. The osteoclast-like cells seemed to arise from fusion of monohistiocytic cells. Immature fibroblastic cells, occasionally containing filaments with densities were also present. They were scarce in 3 cases and predominant in the 4th. MGCT is a mesenchymal sarcoma with a bimorphic monohistiocytic and fibroblastic differentiation. MGCT is considered a special variant of malignant fibrous histiocytoma.