Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinius

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Abstract
Specific antibodies isolated by immunoadsorption on four main insolubilized allergens from Dermatophagoides pteronyssinus (DPT) had the following isotypic distribution: in 16 atopic patients, 52%, IgG, 40% IgM, 8% IgA, 0.1% IgE and, in 12 non-atopic individuals, 48% IgG, 46% IgM, 6% IgA, 0.03% IgE. The ratios between geometric means of antibody values in each class (atopic vs non-atopics) were 2.4 for IgG, 2.0 for IgM, 2.8 for IgA and 66.7 for IgE. The amount of anti-DPT antibodies in IgG subclasses did not follow the usual distribution of total IgG subclasses, i.e., IgG1 > IgG2 > IgG3 > IgG4. In atopics the order was IgG2 > IgG1 > IgG4 > IgG3 and in non-atopics, IgG4 > IgG1 = IgG2 > IgG3 although 6/12 of the latter had no detectable (< 0.5 .mu.g/ml plasma) IgG4.