The immunological synapse: a focal point for endocytosis and exocytosis
Open Access
- 3 May 2010
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 189 (3) , 399-406
- https://doi.org/10.1083/jcb.201002027
Abstract
There are many different cells in the immune system. To mount an effective immune response, they need to communicate with each other. One way in which this is done is by the formation of immunological synapses between cells. Recent developments show that the immune synapse serves as a focal point for exocytosis and endocytosis, directed by centrosomal docking at the plasma membrane. In this respect, formation of the immunological synapse bears striking similarities to cilia formation and cytokinesis. These intriguing observations suggest that the centrosome may play a conserved role in designating a specialized area of membrane for localized endocytosis and exocytosis.Keywords
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