The Effect of some Anti-Diarrhoeal Drugs on Intestinal Transit and Faecal Excretion of Water and Electrolytes in the Horse

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Abstract
The effect of morphine, tinct. opii [tincture of opium], loperamide, pethidine and atropine on intestinal transit and the fecal and urinary excretion of water and electrolytes was studied in ponies. The rate of passage of a particulate marker was slowed by morphine, hastened then slowed by loperamide and tinct. opii and hastened by atropine. The liquid marker was slowed by tinct. opii and hastened then slowed by the other drugs. Only loperamide decreased the fecal Na excretion. This drug also decreased fecal water and wt; it appeared worthy of clinical trial in diarrhea. Tinct. opii decreased but morphine, pethidine and atropine increased fecal water.