RADIO-IODINE INDUCED ATHYROID JOINT DISEASE IN MICE OF DIFFERENT STRAINS1
- 1 November 1954
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 55 (5) , 535-542
- https://doi.org/10.1210/endo-55-5-535
Abstract
Male mice of strain C57BL radio-thyroldectomized with I131 at the age of 6 months develop an athyrold arthropathy which is less frequent and strikingly less severe than in DBA mice treated similarly. These strain differences in susceptibility to athyroidism are explained on the basis of strain differences in thyroid activity in the 2 strains, DBA mice showing physiologically hyperactive thyroids as compared to those of C57 mice. On the other hand, C57 mice had a higher incidence of hypophyseal tumors induced by the isotope than mice of strain DBA.Keywords
This publication has 4 references indexed in Scilit:
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- Hormone-Secreting Transplantable Neoplasms of the Pituitary Induced by I131.Experimental Biology and Medicine, 1951
- GROWTH AND ARTICULAR CHANGES IN SLOWLY AND RAPIDLY DEVELOPING MICE FED A HIGH-FAT DIET1950
- Tumorous Growths in the Pituitary and Trachea Following Radio toxic Dosages of I131.Experimental Biology and Medicine, 1949