Pseudomonas aeruginosa and Acinetobacter calcoaceticus: In vitro Susceptibility of 150 Clinical Isolates to Five β-Lactam Antibiotics and Tobramycin

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Abstract
The in vitro activities of azlocillin, carbenicillin, ceftriaxone, piperacillin, N-formimidoyl thienamycin (N-f thienamycin) and tobramycin were compared against clinical isolates of P. aeruginosa (100) and A. calcoaceticus (50). An agar dilution method was employed for measurement of minimal inhibitory concentration (MIC). Tobramycin was the most active drug against P. aeruginosa (MIC .ltoreq. 2 mg/l). Of the .beta.-lactam antibiotics, N-f thienamycin showed the highest activity; carbenicillin was least active. N-f thienamycin and tobramycin were highly active against A. calcoaceticus (MIC .ltoreq. 2 mg/l), although 1 isolate was resistant to tobramycin (MIC > 16 mg/l). The other drugs were only moderately active against A. calcoaceticus.