A stereoselective total synthesis of 11-oxoprogesterone, a precursor to the corticosteroids, via an intramolecular cycloaddition reaction
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1621-1625
- https://doi.org/10.1039/p19860001621
Abstract
A Stereoselective synthesis of 11-oxoprogesterone (pregn-4-ene-3,11,20-trione)(21) has been achieved via 19-norpregna-4,9(10)-diene-3,20-dione (14) and pregna-4,9(10)-diene-3,20-dione (18). The compound (14) was derived from the des-A,B-aromatic steroid (6), which was, in turn, constructed in a stereoselective manner via(3) by the thermolysis of the olefinic benzocyclobutene (2).This publication has 5 references indexed in Scilit:
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