Neuropathies Associated with Paraproteinemia

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Abstract
A number of common disorders of the peripheral nervous system, termed paraproteinemic neuropathies, are closely connected with the presence of excessive amounts of an abnormal immunoglobulin in the blood. These immunoglobulins can be detected by immunoelectrophoresis or the more sensitive immunofixation test. An estimated 10 percent of idiopathic polyneuropathies are of this type.13 The anomalous blood proteins are usually monoclonal (termed M protein or M spike) and are the product of a single clone of plasma cells. They are clinically important because some of them have the properties of antibodies directed at components of the myelin or the axolemma. . . .