Pharmacological Studies on Cistanchis Herba. I. Effects of the Constituents of Cistanchis Herba on Sex and Learning Behavior in Chronic Stressed Mice (1)

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Abstract
The effects of the constituents of Cistanchis Herba [Cistanche salsa (C.A. MEY.) G. BECK, Orobanchaceae] on sex (licking, mounting and intromission) and learning behaviors in IV-CS strain adult male mice were studied according to the chronic hanging stress method modified by Saito et al. The following results were obtained. The phenylpropanoid glycosides fraction (20 mg/kg, p.o.) prepared from cistanchis Herba showed a marked protective effect against decreases of both sex and learning behaviors in the hanging stress loaded mice. The constituents, acteoside (10 mg/kg, p.o.), cistanoside A (10 mg/kg, p.o) and cistanoside C (10 mg/kg, p.o.) also showed almost the same effects. Echinacoside (10 mg/kg, p.o.) showed a protective effect against decreases of sex behavior, but had little effect on learning behavior.

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