Collagen Synthesis: A Disulfide-Linked Collagen Precursor in Chick Bone
- 1 October 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (10) , 2993-2996
- https://doi.org/10.1073/pnas.70.10.2993
Abstract
Chick calvaria labeled in vitro contain a triple-stranded collagen precursor that contains two pro alpha1 and one pro alpha2 chains. All chains contain cystine and are linked by S-S bonds. Ultracentrifugal analysis was used to measure the relative size of the disulfide-linked units. It is proposed that the S-S links help to determine the correct alignment of the triple-stranded structure.Keywords
This publication has 11 references indexed in Scilit:
- Secretion and Extracellular Processing of Procollagen by Cultured Human FibroblastsProceedings of the National Academy of Sciences, 1973
- Precursors of Collagen Secreted by Cultured Human FibroblastsProceedings of the National Academy of Sciences, 1972
- High molecular weight collagen: A long-lived intermediate in the biogenesis of collagen fibrilsBiochemical and Biophysical Research Communications, 1972
- Collagen synthesis by cells II: Secretion of a disulfide linked materialBiochemical and Biophysical Research Communications, 1972
- A Transport Form of Collagen from Embryonic Tendon: Electron Microscopic Demonstration of an NH 2 -Terminal Extension and Evidence Suggesting the Presence of Cystine in the MoleculeProceedings of the National Academy of Sciences, 1972
- Evidence for Procollagen, a Biosynthetic Precursor of CollagenProceedings of the National Academy of Sciences, 1971
- The Nature of the Collagen Synthesized by Cultured Human FibroblastsProceedings of the National Academy of Sciences, 1971
- Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfideBiochemical and Biophysical Research Communications, 1969
- GAMMA TROPOCOLLAGEN: A REVERSIBLY DENATURABLE COLLAGEN MACROMOLECULEProceedings of the National Academy of Sciences, 1961