The bioavailabilities of aspirin from an aspirin aluminum and an aspirin tablets and the effects of food and aluminum hydroxide gel.

Publisher Website
Google Scholar
Abstract
Aspi-in bioavailability from an aspirin aluminum tablet was compared with that from an aspirin tablet in humans by determining total salicylate excreted in the urine. The effects of concomitant intakes of antacid or food on aspirin bioavailability were investigated. Aspirin bioavailability from an aspirin aluminum tablet was nearly 60% of that from an aspirin tablet. The low aspirin bioavailability from an aspirin aluminum tablet was caused by slow release of aspirin from the aluminum complex, and not increased by concomitant intake of food. Food intake reduced both rate and extent of aspirin bioavailability from an aspirin tablet, but dried aluminum hydroxide gel granules had no effect.

This publication has 6 references indexed in Scilit: