Comparison of the incidence of oncogenic transformation produced by X rays, misonidazole, and chemotherapy agents.

Publisher Website
Google Scholar
Abstract
An established line of mouse fibroblasts (10 T 1/2 cells) cultured in vitro was used to compare the incidence of oncogenic transformation produced by X rays, the hypoxic cell radiosensitizer misonidazole and a range of commonly used chemotherapy agents [vincristine, melphalan, adriamycin, cis-platinum and 5-azacitidine]. A 3-day exposure to misonidazole at a concentration obtainable during treatment produced an incidence of transformation similar to that of .apprx. 50 rad. When chemotherapy agents were tested at concentrations comparable to those used clinically and matched to produce similar cell killing, the incidence of transformation varied widely: some agents, such as vincristine, did not produce transformation at a level detectable above background, while others, such as cis-platinum, appear to be potent carcinogens and produce transformation at a rate orders of magnitude higher than that achieved with X rays.