EFFECT OF INTRAVENOUS CALCIUM GLUCONATE UPON THE EXCRETION OF CALCIUM AND PHOSPHORUS IN PATIENTS WITH IDIOPATHIC HYPOPARATHYROIDISM*

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Abstract
Two courses of 500 ml. of 3% Ca gluconate soln. were admn. to each of 3 patients with idiopathic hypoparathyroidism resulting in an elevated serum Ca. Initially insignificant urinary Ca excretion suddenly increased when the serum Ca concn. rose above a value which was critical for a given patient, but which was somewhat variable from patient to patient. Above this critical level Ca excretion appeared to increase linearly, suggesting a reabsorption. The rate of Ca excretion under these circumstances was greater than that of a normal individual with the same serum Ca concn., indicating that the mechanism in these patients was still not normal. Following the rise in the serum Ca levels, there was a marked rise in the concn. of serum P. This response was associated with a comparable increase in urine P excretion.

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