Effect of acetylcholine on urinary electrolyte excretion

Publisher Website
Google Scholar
Abstract
Acetylcholine was infused into the aorta of unanesthetized dogs above the origin of the renal arteries. It produced a statistically significant increase in Na, Cl, and K excretion rates and in renal plasma flow with respect to control values in the same experiments and to results obtained in separate control experiments on the same animals. No consistent change was found in glomerular filtration rate, urine flow, and osmolality. In similar experiments Pitressin was also infused. The renal effects of acetylcholine were slightly enhanced by Pitressin. It was concluded that the antidiuretic hormone was not an important mediator in the production of renal effects during acetylcholine infusion. The possible roles of increased medullary blood flow and of increased angiotensin production are discussed.

This publication has 5 references indexed in Scilit: